One example is a trick in which a gene allows a cell, even as the drug approaches the cell, 有一个例子很神奇,基因能让细胞在药物接近之前, to push the drug out, before the drug can have any effect. 把药物推开,药物根本来不及起任何作用。 Imagi
Cancer affects all of us -- especially the ones that come back over and over again, 癌症是我们每个人的大敌--尤其是那些不断复发的, the highly invasive and drug-resistant ones, the ones that defy medical treatment, 容易扩散的,具有
But there is one more big obstacle we have to think about. 但前方还有一个大障碍需要跨越。 In fact, it may be the biggest obstacle of all. 而且,也许是最大的一个障碍。 How do we deploy this superweapon? 我们该如何部署这件超级武器? I mean, ever
What's great about this approach is that it can be personalized. 这种方法最大的好处就是可以定制。 We can add many different layers of siRNA to address different mutations and tumor defense mechanisms. 我们可以添加多重siRNA,分
The siRNA is deployed first. It acts for hours, giving enough time to silence and block those survival genes. siRNA首先开始行动。它需要几个小时,来让(癌细胞的)生存基因失效。 We have now disabled those genetic superpowers. 我们去除了(
So, here's our strategy. First, we'll dose the cancer cell with siRNA, the gene blocker, 因此,我们的策略如下。首先,我们将siRNA--基因拦截者,用在癌细胞身上, and silence those survival genes, and then we'll whop it with a chemo dr
As a researcher, I usually don't get to work with patients. 作为一名研究者,我通常很少与病人接触。 But I recently met a mother who is an ovarian cancer survivor, Mimi, and her daughter, Paige. 但最近我遇到了一位母亲,她叫咪咪,是一名卵巢癌幸存者